TY - JOUR
T1 - Poly(urethane)-crossunked poly(hema) hydrogels
AU - Cohn, Daniel
AU - Aronhime, Marc
AU - Abdo, Bashir
PY - 1992/10/1
Y1 - 1992/10/1
N2 - Hydrogels have been prepared from 2-hydroxyethyl methacrylate polymerized in the presence of isocyanate-terminated poly(ethylene glycol) (PEG) crosslinking agents. PEGs of molecular weights 200, 400, and 1000 were investigated. The crosslinked nature of the hydrogelswas demonstrated by their insolubility in solvents which normally dissolve poly(HEMA). Hexamethylene diisocyanate (HDI) was mainly used as the isocyanate. The molecular weight of the PEG and the crosslinker content significantly influenced the equilibrium water sorption and mechanical properties of the saturated networks. It was observed that as the molecular weightof the PEG increased, the water sorption increased and the nominal modulus decreased. However, for higher levels of crosslinker, water sorption decreased and modulus increased at lowmolecular weight PEG; for PEG 1000, water absorption increased as crosslinker content increased. These results are explained by the competing effects of flexibility, crosslink density,and hydrophobicity contributed by the various constituents of the hydrogels.
AB - Hydrogels have been prepared from 2-hydroxyethyl methacrylate polymerized in the presence of isocyanate-terminated poly(ethylene glycol) (PEG) crosslinking agents. PEGs of molecular weights 200, 400, and 1000 were investigated. The crosslinked nature of the hydrogelswas demonstrated by their insolubility in solvents which normally dissolve poly(HEMA). Hexamethylene diisocyanate (HDI) was mainly used as the isocyanate. The molecular weight of the PEG and the crosslinker content significantly influenced the equilibrium water sorption and mechanical properties of the saturated networks. It was observed that as the molecular weightof the PEG increased, the water sorption increased and the nominal modulus decreased. However, for higher levels of crosslinker, water sorption decreased and modulus increased at lowmolecular weight PEG; for PEG 1000, water absorption increased as crosslinker content increased. These results are explained by the competing effects of flexibility, crosslink density,and hydrophobicity contributed by the various constituents of the hydrogels.
UR - http://www.scopus.com/inward/record.url?scp=0026989427&partnerID=8YFLogxK
U2 - 10.1080/10601329208054122
DO - 10.1080/10601329208054122
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AN - SCOPUS:0026989427
SN - 1060-1325
VL - 29
SP - 841
EP - 851
JO - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
JF - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
IS - 10
ER -