Population-based gene discovery in the post-genomic era

Naomi B. Zak*, Sagiv Shifman, Anne Shalom, Ariel Darvasi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The complex genetic nature of many common diseases makes the identification of the genes that predispose to these ailments a difficult task. Consequently, many factors have to be considered in choosing the optimal approach to be taken in gene discovery of susceptibility genes. The elements to be considered include the applicability of a family-based linkage paradigm versus a population-based association design and the effects of linkage disequilibrium (LD) and genotypic relative risk (GRR). In this review we discuss these various points and describe the impact on LD and GRR of studying an isolated (also termed 'founder' or 'homogeneous') population, such as Ashkenazi Jews, as compared to an outbred population, such as Caucasians.

Original languageAmerican English
Pages (from-to)1111-1115
Number of pages5
JournalDrug Discovery Today
Issue number21
StatePublished - 1 Nov 2001


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