TY - JOUR
T1 - Population pharmacokinetic analysis of the active product of dipyrone
AU - Levy, M.
AU - Muszkat, M.
AU - Rich, B.
AU - Rosenkranz, B.
AU - Schlattmann, P.
PY - 2010/12
Y1 - 2010/12
N2 - Objective: Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied. Study design and setting: 153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel. Intervention: Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statistical analysis: Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored. Results: The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age. Conclusion:Apopulation pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition.
AB - Objective: Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied. Study design and setting: 153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel. Intervention: Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statistical analysis: Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored. Results: The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age. Conclusion:Apopulation pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition.
KW - Clearance
KW - Dipyrone
KW - MAA
KW - Nonlinear mixed effects models
KW - Population pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=78650848624&partnerID=8YFLogxK
U2 - 10.5414/CPP48791
DO - 10.5414/CPP48791
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AN - SCOPUS:78650848624
SN - 0946-1965
VL - 48
SP - 791
EP - 797
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
IS - 12
ER -