TY - JOUR
T1 - Porous silicon substrates for neurons culturing and bio-photonic sensing
AU - De-Leon, S. Ben Tabou
AU - Oren, R.
AU - Spira, M. E.
AU - Korbakov, N.
AU - Yitzchaik, S.
AU - Sa'ar, A.
PY - 2005/6
Y1 - 2005/6
N2 - In this work we report on culturing of Aplysia neurons and vertebrate cells to porous silicon substrates and on the first steps toward characterizing porous silicon as a biosensor of neural activity. Neurons cultured on porous silicon substrates survived for at least one week showing normal passive membrane properties and generation of action potentials. We have investigated several mechanisms that take advantage of the optical properties of porous silicon for transducing both electrical and chemical neuronal activities into photonic signals. For example, the photoluminescence response to voltage and the reflectivity response to chemical changes were investigated.
AB - In this work we report on culturing of Aplysia neurons and vertebrate cells to porous silicon substrates and on the first steps toward characterizing porous silicon as a biosensor of neural activity. Neurons cultured on porous silicon substrates survived for at least one week showing normal passive membrane properties and generation of action potentials. We have investigated several mechanisms that take advantage of the optical properties of porous silicon for transducing both electrical and chemical neuronal activities into photonic signals. For example, the photoluminescence response to voltage and the reflectivity response to chemical changes were investigated.
UR - http://www.scopus.com/inward/record.url?scp=25444469122&partnerID=8YFLogxK
U2 - 10.1002/pssa.200461136
DO - 10.1002/pssa.200461136
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AN - SCOPUS:25444469122
SN - 1862-6300
VL - 202
SP - 1456
EP - 1461
JO - Physica Status Solidi (A) Applications and Materials Science
JF - Physica Status Solidi (A) Applications and Materials Science
IS - 8
ER -