Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Pankaz K. Sharma; Rouslan Kevorkiants; Sam P. De Visser; Devesh Kumar; Sason Shaik

doi:10.1002/anie.200352943

Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Pankaz K. Sharma, Rouslan Kevorkiants, Sam P. De Visser, Devesh Kumar, Sason Shaik^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme-oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.

Original language	English
Pages (from-to)	1129-1132
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	9
DOIs	https://doi.org/10.1002/anie.200352943
State	Published - 20 Feb 2004

Keywords

Density functional calculations
Enzyme catalysis
Enzyme models
Heme proteins
Oxygenation

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10.1002/anie.200352943

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AU - De Visser, Sam P.

AU - Kumar, Devesh

AU - Shaik, Sason

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KW - Enzyme catalysis

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KW - Oxygenation

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Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

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Keywords

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