Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs

Martin Pierre Youenang Piemi, Daniel Korner, Simon Benita, Jean Paul Marty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Charged submicron emulsions are a priori interesting candidates for the delivery of drugs in and/or through the skin. In the present study, it was possible by using stearylamine or deoxycholic acid (DCA) to incorporate either econazole or miconazole nitrate, respectively, in positively and negatively charged submicron emulsions. The investigation of the relationship between the physicochemical properties of the vehicles, especially the charge of the emulsion and skin permeation, was conducted ex vivo during percutaneous absorption experiments using hairless female rat skin. In addition, drug quantification was carried out using two different analytical techniques (HPLC and radioactivity measurements) in order to examine if the drug analysis approach might affect the results. The results clearly indicate that the surface-modified droplets have a significant influence on the diffusion through the skin. Furthermore, the method of preparation of the formulation and subsequently the analytical method of drug concentration measurement are able to influence the results of percutaneous experiments. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalJournal of Controlled Release
Volume58
Issue number2
DOIs
StatePublished - 29 Mar 1999

Keywords

  • Econazole nitrate
  • Miconazole nitrate
  • Negatively charged
  • Percutaneous absorption
  • Positively charged
  • Submicron emulsion

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