TY - JOUR
T1 - Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs
AU - Youenang Piemi, Martin Pierre
AU - Korner, Daniel
AU - Benita, Simon
AU - Marty, Jean Paul
PY - 1999/3/29
Y1 - 1999/3/29
N2 - Charged submicron emulsions are a priori interesting candidates for the delivery of drugs in and/or through the skin. In the present study, it was possible by using stearylamine or deoxycholic acid (DCA) to incorporate either econazole or miconazole nitrate, respectively, in positively and negatively charged submicron emulsions. The investigation of the relationship between the physicochemical properties of the vehicles, especially the charge of the emulsion and skin permeation, was conducted ex vivo during percutaneous absorption experiments using hairless female rat skin. In addition, drug quantification was carried out using two different analytical techniques (HPLC and radioactivity measurements) in order to examine if the drug analysis approach might affect the results. The results clearly indicate that the surface-modified droplets have a significant influence on the diffusion through the skin. Furthermore, the method of preparation of the formulation and subsequently the analytical method of drug concentration measurement are able to influence the results of percutaneous experiments. Copyright (C) 1999 Elsevier Science B.V.
AB - Charged submicron emulsions are a priori interesting candidates for the delivery of drugs in and/or through the skin. In the present study, it was possible by using stearylamine or deoxycholic acid (DCA) to incorporate either econazole or miconazole nitrate, respectively, in positively and negatively charged submicron emulsions. The investigation of the relationship between the physicochemical properties of the vehicles, especially the charge of the emulsion and skin permeation, was conducted ex vivo during percutaneous absorption experiments using hairless female rat skin. In addition, drug quantification was carried out using two different analytical techniques (HPLC and radioactivity measurements) in order to examine if the drug analysis approach might affect the results. The results clearly indicate that the surface-modified droplets have a significant influence on the diffusion through the skin. Furthermore, the method of preparation of the formulation and subsequently the analytical method of drug concentration measurement are able to influence the results of percutaneous experiments. Copyright (C) 1999 Elsevier Science B.V.
KW - Econazole nitrate
KW - Miconazole nitrate
KW - Negatively charged
KW - Percutaneous absorption
KW - Positively charged
KW - Submicron emulsion
UR - http://www.scopus.com/inward/record.url?scp=0032993019&partnerID=8YFLogxK
U2 - 10.1016/S0168-3659(98)00156-4
DO - 10.1016/S0168-3659(98)00156-4
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 10053190
AN - SCOPUS:0032993019
SN - 0168-3659
VL - 58
SP - 177
EP - 187
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -