Possible association between IL-2 receptors and class I HLA molecules on T cells

M. Sharon, J. R. Gnarra, M. Baniyash, W. J. Leonard

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

In the process of evaluating murine hybridomas for an antibody to the β-subunit of the IL-2R (p70) we identified an antibody that immunoprecipitated a 55- to 57-kDa complex from cross-linked lysates. We demonstrate that this complex is composed of IL-2 (15.5 kDa) cross-linked to the H chain of HLA class I (40 to 42 kDa), suggesting a molecular interaction between HLA class I molecules and IL-2R. Although the exact role of this association remains to be determined, the specific cross-linking of IL-2 to HLA class I Ag is intriguing in view of published claims for a role of HLA class I in OKT3-induced lymphocyte proliferation and in NK cell lytic activity.

Original languageAmerican English
Pages (from-to)3512-3515
Number of pages4
JournalJournal of Immunology
Volume141
Issue number10
StatePublished - 1988
Externally publishedYes

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