Possible association between SP-C mutations and lung cancer: Two case reports and review of literature

Fares Darawshy*, Ayman Abu Rmeileh, Rottem Kuint, Neville Berkman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Surfactant protein C (SP-C) is one of four surfactant proteins produced by type II pneumocytes. Mutations in surfactant protein A are strongly associated with development of lung cancer. Mutations in the SP-C gene are rare and are associated with interstitial lung disease in the pediatric age group. We describe two patients with SP-C mutations who developed lung cancer. Both patients had concurrent interstitial lung disease, although the clinical phenotype was variable. In both cases, mutations were in translated region of the SP-C gene; one in the BRICHOS domain and the other in the transmembrane domain. Our paper suggests that patients with SP-C mutations can be at increased risk for the development of lung cancer, and it's reasonable to follow them routinely.

Original languageAmerican English
Article number100461
JournalCancer Treatment and Research Communications
Volume29
DOIs
StatePublished - Jan 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Adenocarcinoma
  • Lung cancer
  • SP-C
  • Surfactant

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