Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

R. Reich; F. Kohen; Z. Naor; A. Tsafriri

doi:10.1016/0090-6980(83)90161-2

Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

R. Reich^*
, F. Kohen
, Z. Naor
, A. Tsafriri

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The possible involvement of products of the lipoxygenase pathway of archidonic acid cascade in ovulation was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA); 5,8,11-eicosatriynoic acid (5,8,11-ETYA), 3 amino-1-(3 trifluromethyphenyl)-2-pyrazoline hydrochloride (BW755c) and (FPL 55712). All these drugs reduced the number of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was most potent since it completely blocked ovulation from the treated ovaried in 17/38 rats receiving a dose higher than 0.15 mg/ bursa. This effect og NDGA cannot be ascribed to its inhibition of ovarian PGE synthesis. Conversion of labeled arachidonic acid and via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC chromatography. Collectively, these results suggest the involvement of products of lipoxygenase pathway of arachidonic acid in ovulation in the rat.

Original language	English
Pages (from-to)	1011-1020
Number of pages	10
Journal	Prostaglandins
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(83)90161-2
State	Published - Dec 1983
Externally published	Yes

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@article{53e4648635bb4a689406ac2420d2543c,

title = "Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation",

abstract = "The possible involvement of products of the lipoxygenase pathway of archidonic acid cascade in ovulation was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA); 5,8,11-eicosatriynoic acid (5,8,11-ETYA), 3 amino-1-(3 trifluromethyphenyl)-2-pyrazoline hydrochloride (BW755c) and (FPL 55712). All these drugs reduced the number of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was most potent since it completely blocked ovulation from the treated ovaried in 17/38 rats receiving a dose higher than 0.15 mg/ bursa. This effect og NDGA cannot be ascribed to its inhibition of ovarian PGE synthesis. Conversion of labeled arachidonic acid and via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC chromatography. Collectively, these results suggest the involvement of products of lipoxygenase pathway of arachidonic acid in ovulation in the rat.",

author = "R. Reich and F. Kohen and Z. Naor and A. Tsafriri",

year = "1983",

month = dec,

doi = "10.1016/0090-6980(83)90161-2",

language = "אנגלית",

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TY - JOUR

T1 - Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

AU - Reich, R.

AU - Kohen, F.

AU - Naor, Z.

AU - Tsafriri, A.

PY - 1983/12

Y1 - 1983/12

N2 - The possible involvement of products of the lipoxygenase pathway of archidonic acid cascade in ovulation was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA); 5,8,11-eicosatriynoic acid (5,8,11-ETYA), 3 amino-1-(3 trifluromethyphenyl)-2-pyrazoline hydrochloride (BW755c) and (FPL 55712). All these drugs reduced the number of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was most potent since it completely blocked ovulation from the treated ovaried in 17/38 rats receiving a dose higher than 0.15 mg/ bursa. This effect og NDGA cannot be ascribed to its inhibition of ovarian PGE synthesis. Conversion of labeled arachidonic acid and via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC chromatography. Collectively, these results suggest the involvement of products of lipoxygenase pathway of arachidonic acid in ovulation in the rat.

AB - The possible involvement of products of the lipoxygenase pathway of archidonic acid cascade in ovulation was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA); 5,8,11-eicosatriynoic acid (5,8,11-ETYA), 3 amino-1-(3 trifluromethyphenyl)-2-pyrazoline hydrochloride (BW755c) and (FPL 55712). All these drugs reduced the number of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was most potent since it completely blocked ovulation from the treated ovaried in 17/38 rats receiving a dose higher than 0.15 mg/ bursa. This effect og NDGA cannot be ascribed to its inhibition of ovarian PGE synthesis. Conversion of labeled arachidonic acid and via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC chromatography. Collectively, these results suggest the involvement of products of lipoxygenase pathway of arachidonic acid in ovulation in the rat.

UR - https://www.scopus.com/pages/publications/0021021839

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AN - SCOPUS:0021021839

SN - 0090-6980

VL - 26

SP - 1011

EP - 1020

JO - Prostaglandins

JF - Prostaglandins

IS - 6

ER -

Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

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