Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Patrizia Barozzi; Mario Luppi; Fabio Faccheti; Cristina Mecucci; Milena Alù; Ronit Sarid; Valeria Rasini; Luisa Ravazzini; Elisa Rossi; Silvana Festa; Barbara Crescenzi; Dana G. Wolf; Thomas F. Schulz; Giuseppe Torelli

doi:10.1038/nm862

Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Patrizia Barozzi, Mario Luppi^*, Fabio Faccheti, Cristina Mecucci, Milena Alù, Ronit Sarid, Valeria Rasini, Luisa Ravazzini, Elisa Rossi, Silvana Festa, Barbara Crescenzi, Dana G. Wolf, Thomas F. Schulz, Giuseppe Torelli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

Original language	English
Pages (from-to)	554-561
Number of pages	8
Journal	Nature Medicine
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/nm862
State	Published - 1 May 2003
Externally published	Yes

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10.1038/nm862

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title = "Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors",

abstract = "Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.",

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AU - Barozzi, Patrizia

AU - Luppi, Mario

AU - Faccheti, Fabio

AU - Mecucci, Cristina

AU - Alù, Milena

AU - Sarid, Ronit

AU - Rasini, Valeria

AU - Ravazzini, Luisa

AU - Rossi, Elisa

AU - Festa, Silvana

AU - Crescenzi, Barbara

AU - Wolf, Dana G.

AU - Schulz, Thomas F.

AU - Torelli, Giuseppe

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

AB - Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

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Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Abstract

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