Postsynaptic effects of DMSO at the frog neuromuscular junction

Ronit Cherki-Vakil, Halina Meiri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Postsynaptic effects of dimethylsulfoxide (DMSO) were studied at the frog cutaneous pectoris neuromuscular junction using electrophysiological techniques and computer assisted analysis. It was found that the average amplitude of extracellularly recorded miniature end-plate potentials (meppse) as well as the time constant of their monoexponential decay (τ) were both elevated in the presence of DMSO. In spite of increased scatter of individual values, amplitude and τ of meppse highly correlated with each other. These results imply that DMSO partially blocked the activity of acetylcholine esterase in addition to its already known presynaptic action of acetylcholine release enhancement. Inhibitory action of DMSO on activity of isolated acetylcholine esterase was previously demonstrated by biochemical methods.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalBrain Research
Volume566
Issue number1-2
DOIs
StatePublished - 6 Dec 1991

Keywords

  • Acetylcholine esterase
  • Dimethylsulfoxide
  • Synaptic transmission

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