Potassium channels moderate ectopic excitability of nerve-end neuromas in rats

Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalNeuroscience Letters
Volume40
Issue number2
DOIs
StatePublished - 30 Sep 1983

Keywords

  • 4-aminopyridine
  • nerve pathophysiology
  • neuroma
  • pain
  • potassium conductance
  • rat
  • tetraethylammonium

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