Abstract
The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.
Original language | English |
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Pages (from-to) | 181-186 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 40 |
Issue number | 2 |
DOIs | |
State | Published - 30 Sep 1983 |
Keywords
- 4-aminopyridine
- nerve pathophysiology
- neuroma
- pain
- potassium conductance
- rat
- tetraethylammonium