Potassium channels moderate ectopic excitability of nerve-end neuromas in rats

Marshall Devor

doi:10.1016/0304-3940(83)90299-9

Potassium channels moderate ectopic excitability of nerve-end neuromas in rats

Marshall Devor^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.

Original language	English
Pages (from-to)	181-186
Number of pages	6
Journal	Neuroscience Letters
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(83)90299-9
State	Published - 30 Sep 1983

Keywords

4-aminopyridine
nerve pathophysiology
neuroma
pain
potassium conductance
rat
tetraethylammonium

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10.1016/0304-3940(83)90299-9

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abstract = "The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.",

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KW - nerve pathophysiology

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KW - pain

KW - potassium conductance

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Potassium channels moderate ectopic excitability of nerve-end neuromas in rats

Abstract

Keywords

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