Potent anti-inflammatory activity of 3-aminovinylphosphonates as inhibitors of reactive oxygen intermediates, nitric oxides generation, and tumor necrosis factor-alpha release

Abed Al Aziz Al Quntar, Ruth Gallily, Galia Katzavian, Morris Srebnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Two 3-aminoalkenylphosphonate compounds 1, 2, and a hydroxyl derivative, 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3, recently synthesized in our lab, have been evaluated for their ability to modulate the production of reactive oxygen intermediates, nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages. We found that all three molecules suppressed generation of reactive oxygen intermediates, NO, and TNF-α. However, although 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3 possessed higher activity in suppression of reactive oxygen intermediates and nitric oxide compared to 3-aminoalkenylphosphonates 1 and 2, it showed less activity in the inhibition of tumor necrosis factor release.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalEuropean Journal of Pharmacology
Volume556
Issue number1-3
DOIs
StatePublished - 5 Feb 2007

Keywords

  • Aminovinylphosphonate
  • Anti-inflammatory
  • Hydroxyvinylphosphonate
  • Nitric oxide
  • Reactive oxygen intermediate
  • Tumor necrosis factor-alpha

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