TY - JOUR
T1 - Potent anti-inflammatory activity of 3-aminovinylphosphonates as inhibitors of reactive oxygen intermediates, nitric oxides generation, and tumor necrosis factor-alpha release
AU - Quntar, Abed Al Aziz Al
AU - Gallily, Ruth
AU - Katzavian, Galia
AU - Srebnik, Morris
PY - 2007/2/5
Y1 - 2007/2/5
N2 - Two 3-aminoalkenylphosphonate compounds 1, 2, and a hydroxyl derivative, 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3, recently synthesized in our lab, have been evaluated for their ability to modulate the production of reactive oxygen intermediates, nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages. We found that all three molecules suppressed generation of reactive oxygen intermediates, NO, and TNF-α. However, although 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3 possessed higher activity in suppression of reactive oxygen intermediates and nitric oxide compared to 3-aminoalkenylphosphonates 1 and 2, it showed less activity in the inhibition of tumor necrosis factor release.
AB - Two 3-aminoalkenylphosphonate compounds 1, 2, and a hydroxyl derivative, 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3, recently synthesized in our lab, have been evaluated for their ability to modulate the production of reactive oxygen intermediates, nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages. We found that all three molecules suppressed generation of reactive oxygen intermediates, NO, and TNF-α. However, although 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3 possessed higher activity in suppression of reactive oxygen intermediates and nitric oxide compared to 3-aminoalkenylphosphonates 1 and 2, it showed less activity in the inhibition of tumor necrosis factor release.
KW - Aminovinylphosphonate
KW - Anti-inflammatory
KW - Hydroxyvinylphosphonate
KW - Nitric oxide
KW - Reactive oxygen intermediate
KW - Tumor necrosis factor-alpha
UR - http://www.scopus.com/inward/record.url?scp=33846097671&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2006.10.041
DO - 10.1016/j.ejphar.2006.10.041
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C2 - 17161836
AN - SCOPUS:33846097671
SN - 0014-2999
VL - 556
SP - 9
EP - 13
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -