TY - JOUR
T1 - Preclinical and clinical experience with a doxorubicin-liposome preparation
AU - Gabizon, Alberto
AU - Amselem, Shimon
AU - Goren, Dorith
AU - Cohen, Rivka
AU - Druckmann, Shulamith
AU - Fromer, Ilana
AU - Chisin, Roland
AU - Peretz, Tamar
AU - Sulkes, Aaron
AU - Barenholz, Yechezkel
PY - 1990
Y1 - 1990
N2 - Entrapment of doxorubicin in liposomes results in increased drug concentrations in liver and spleen and decreased uptake by the heart muscle. these pharmacologic changes can be exploited to reduce the drug's toxicity and increase its therapeutic index in selected neoplastic conditions. We review here our preclinical and phase I clinical data with liposome-associated doxorubicin. these studies, together with preliminary observations on the pharmacokinetics of the liposome-associated drug and on the imaging of radiolabeled vesicles in patients, suggest that the maximal tolerated dosage is significantly increased over that of the free drug and that the reticuloendothelial system is responsible for the rapid and dominant pathway of liposome clearance. the implications of various pharmacologic aspects of liposome behavior in the circulation are also discussed.
AB - Entrapment of doxorubicin in liposomes results in increased drug concentrations in liver and spleen and decreased uptake by the heart muscle. these pharmacologic changes can be exploited to reduce the drug's toxicity and increase its therapeutic index in selected neoplastic conditions. We review here our preclinical and phase I clinical data with liposome-associated doxorubicin. these studies, together with preliminary observations on the pharmacokinetics of the liposome-associated drug and on the imaging of radiolabeled vesicles in patients, suggest that the maximal tolerated dosage is significantly increased over that of the free drug and that the reticuloendothelial system is responsible for the rapid and dominant pathway of liposome clearance. the implications of various pharmacologic aspects of liposome behavior in the circulation are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=0025636479&partnerID=8YFLogxK
U2 - 10.3109/08982109009036010
DO - 10.3109/08982109009036010
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AN - SCOPUS:0025636479
SN - 0898-2104
VL - 1
SP - 491
EP - 502
JO - Journal of Liposome Research
JF - Journal of Liposome Research
IS - 4
ER -