TY - JOUR
T1 - Predicting molecular interactions in silico
T2 - II. Protein-protein and protein-drug docking
AU - Schneidman-Duhovny, Dina
AU - Nussinov, Ruth
AU - Wolfson, Haim J.
PY - 2004
Y1 - 2004
N2 - This article reviews the docking field starting from basic docking algorithms and describing the latest advances. We present the algorithmic framework and classify the state of-the-art methods. We point out the bottlenecks of the methods, like flexibility, absence of absolute scoring functions and explain what types of information can potentially be added to improve the results.
AB - This article reviews the docking field starting from basic docking algorithms and describing the latest advances. We present the algorithmic framework and classify the state of-the-art methods. We point out the bottlenecks of the methods, like flexibility, absence of absolute scoring functions and explain what types of information can potentially be added to improve the results.
KW - Active site detection
KW - Biomolecular recognition
KW - Computer-aided drug design
KW - Flexibility
KW - Protein-ligand docking
KW - Protein-protein docking
UR - http://www.scopus.com/inward/record.url?scp=0347755444&partnerID=8YFLogxK
U2 - 10.2174/0929867043456223
DO - 10.2174/0929867043456223
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C2 - 14754428
AN - SCOPUS:0347755444
SN - 0929-8673
VL - 11
SP - 91
EP - 107
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 1
ER -