Abstract
This article reviews the docking field starting from basic docking algorithms and describing the latest advances. We present the algorithmic framework and classify the state of-the-art methods. We point out the bottlenecks of the methods, like flexibility, absence of absolute scoring functions and explain what types of information can potentially be added to improve the results.
Original language | American English |
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Pages (from-to) | 91-107 |
Number of pages | 17 |
Journal | Current Medicinal Chemistry |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
Keywords
- Active site detection
- Biomolecular recognition
- Computer-aided drug design
- Flexibility
- Protein-ligand docking
- Protein-protein docking