Prediction of physical performance through muscle enzymes activity

E. Galun, R. Burstein*, I. Tur-Kaspa, E. Assia, Y. Epstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Physical performance deteriorates during strenuous exercise as manifested by a decrease in maximal aerobic power and increased activity of serum muscle enzymes. The relationship between these parameters was investigated in 41 trained subjects during 24 h marches and the following recovery period. Peak O2 uptake and serum activity of creatine phosphokinase (CPK) and glutamic oxalacetic transaminase (GOT) were measured. During the marches there was a simultaneous, significant elevation in serum CPK and GOT activity and a significant reduction in peak O2 uptake. During the early recovery period (24 h) no significant changes occurred in muscle enzyme activity and peak O2 uptake; thereafter (up to 72 h after the end of the march), a gradual decline in enzyme activity levels with a concomitant increase in peak O2 uptake was observed, reaching pre-march values. A "mirror image" relationship between muscle enzyme activity and peak O2 uptake was found during three clearly distinguished phases: a) 24 h march, b) early recovery stage and c) late recovery stage. These findings suggest, that muscle enzyme leakage from muscle cells is closely related to the decline in muscular function and aerobic power. Thus, muscle enzyme activity might be a practical measure of physical performance capacity during the early and late stages of recovery from prolonged endurance exercise.

Original languageAmerican English
Pages (from-to)597-600
Number of pages4
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number5
StatePublished - May 1988
Externally publishedYes


  • Endurance-training
  • Fatigue
  • Muscle enzyme
  • Muscle membrane leakage
  • Physical performance


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