Predictors of risk of nonadherence in outpatients with schizophrenia and other psychotic disorders

Kim A. Weiss, Thomas E. Smith*, James W. Hull, A. Courtney Piper, Jonathan D. Huppert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


We investigated the course of adherence to medication recommendations in 162 patients with psychotic disorders in ambulatory treatment. Data were collected using the clinic's outcome assessment program, maximizing the generalizability of the study. Patients initially adherent to their medication regimens maintained their adherence for an average of 13.3 months. Patients initially nonadherent developed adherence after an average of 5.6 months of treatment. Demographic factors and illness history were unrelated to adherence. This study replicated previous findings of the concurrent association between adherence and global functioning level, substance use, and working alliance with therapist. Cox regression analyses revealed that working alliance, global functioning, and being prescribed clozapine predicted longer maintenance of adherence. Working alliance was the most significant and consistent predictor of adherence to medication recommendations.

Original languageAmerican English
Pages (from-to)341-349
Number of pages9
JournalSchizophrenia Bulletin
Issue number2
StatePublished - 2002
Externally publishedYes


  • Adherence
  • Clozapine
  • Compliance
  • Psychotic disorders
  • Schizophrenia
  • Working alliance


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