Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study

Ronit Calderon-Margalit*, Yechiel Friedlander, Rivka Yanetz, Lisa Deutsch, Mary C. Perrin, Karine Kleinhaus, Efrat Tiram, Susan Harlap, Ora Paltiel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Objective: The purpose of this study was to examine the association between preeclampsia and cancer incidence. Study Design: The Jerusalem Perinatal Study is a population-based cohort of all births to 41,206 residents of Western Jerusalem from 1964-76. Cancer incidence to 2004 was assessed by linkage of the cohort with the Israel Cancer Registry. Cox's proportional hazards models were constructed to estimate the hazard ratio for cancer among women who had had preeclampsia. Results: Preeclampsia was associated with a 1.23-fold increased risk of cancer at all sites, a 37% increased risk of breast cancer, and more than a doubling of ovarian cancer risk. Analysis by morphologic condition yielded significantly increased risks for malignancies that were classed as cystic mucinous and serous (relative risk, 1.96; 95% CI, 1.00-3.83) and for ductal, lobular, and medullary carcinomas (relative risk, 1.40; 95% CI, 1.07-1.83). No differential association was observed by sex of offspring. Conclusion: Our study suggests that the previously described protective effect of preeclampsia on cancer is not universal.

Original languageAmerican English
Pages (from-to)63.e1-63.e5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jan 2009
Externally publishedYes


  • cancer
  • cohort
  • morphologic condition
  • preeclampsia
  • risk
  • sex


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