Pregnancy associated with colon carcinoma overexpressing p53

Nathan Rojansky*, Asher Shushan, Nelly Livni, Oded Jurim, Muggia Sulam, Eithan Galun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The development of colon carcinoma during pregnancy is a rare event. However, when colon carcinoma develops during pregnancy it is considered a lethal coincidence due to rapid progression. We report two rare cases of colon adenocarcinoma diagnosed during gestation. Both tumors displayed increased nuclear immunostaining for p53. The increased expression of p53 in tumor cells could indicate that the p53 gene is either mutated or stabilized or alternatively overexpressed as a responses to DNA damage. It is hypothesized that the development of colon carcinoma during pregnancy can be attributed to alterations of the p53 tumor suppressor gene or gene product on one hand and a maternal immune-tolerant state on the other.

Original languageAmerican English
Pages (from-to)516-520
Number of pages5
JournalGynecologic Oncology
Volume64
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

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