TY - JOUR
T1 - Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers
AU - Diav-Citrin, Orna
AU - Shechtman, Svetlana
AU - Halberstadt, Yehudit
AU - Finkel-Pekarsky, Victoriya
AU - Wajnberg, Rebecka
AU - Arnon, Judy
AU - Di Gianantonio, Elena
AU - Clementi, Maurizio
AU - Ornoy, Asher
PY - 2011/5
Y1 - 2011/5
N2 - Objective: To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs). Study design: Prospective observational cohort regarding pregnancy ACEI/ARBs-exposure including contacts to two Teratology Information Services in Israel (1994-2007) and Italy (1990-2008), with two comparison groups: (1) exposed to other antihypertensives (OAH) (2) after non-teratogenic exposure (NTE) in similar time frames. Results: 252 ACEI/ARBs-exposed, 256 OAH-exposed and 495 NTE-exposed pregnancies were followed-up. The rate of major congenital anomalies was comparable between the groups (8/190, 4.2%, ACEI/ARB; 9/212, 4.2%, OAH; 18/471, 3.8% NTE; p= 0.954) among first trimester exposed pregnancies. The median gestational age at delivery was two weeks earlier, rate of preterm deliveries more than 2-fold higher, and median birth weight more than 200 g lower in the ACEI/ARB and OAH groups compared to the NTE group. Conclusion: The present study suggests that ACEI/ARBs are not major teratogens when used in the first trimester, and can reassure women with similar exposures.
AB - Objective: To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs). Study design: Prospective observational cohort regarding pregnancy ACEI/ARBs-exposure including contacts to two Teratology Information Services in Israel (1994-2007) and Italy (1990-2008), with two comparison groups: (1) exposed to other antihypertensives (OAH) (2) after non-teratogenic exposure (NTE) in similar time frames. Results: 252 ACEI/ARBs-exposed, 256 OAH-exposed and 495 NTE-exposed pregnancies were followed-up. The rate of major congenital anomalies was comparable between the groups (8/190, 4.2%, ACEI/ARB; 9/212, 4.2%, OAH; 18/471, 3.8% NTE; p= 0.954) among first trimester exposed pregnancies. The median gestational age at delivery was two weeks earlier, rate of preterm deliveries more than 2-fold higher, and median birth weight more than 200 g lower in the ACEI/ARB and OAH groups compared to the NTE group. Conclusion: The present study suggests that ACEI/ARBs are not major teratogens when used in the first trimester, and can reassure women with similar exposures.
KW - Angiotensin converting enzyme inhibitors
KW - Angiotensin receptor blockers
KW - Congenital anomalies
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=79956349425&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2011.02.008
DO - 10.1016/j.reprotox.2011.02.008
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C2 - 21338666
AN - SCOPUS:79956349425
SN - 0890-6238
VL - 31
SP - 540
EP - 545
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 4
ER -