TY - JOUR
T1 - Pregnancy outcome following in utero exposure to hydroxychloroquine
T2 - A prospective comparative observational study
AU - Diav-Citrin, Orna
AU - Blyakhman, Shani
AU - Shechtman, Svetlana
AU - Ornoy, Asher
PY - 2013/8
Y1 - 2013/8
N2 - Objective: To evaluate pregnancy safety of hydroxychloroquine (HCQ) for rheumatologic diseases. Design: Prospective comparative observational study done at the Israeli teratology information service between 1998 and 2006. Results: 114 HCQ-exposed pregnancies (98.2% in the first trimester, T1) were followed-up and compared with 455 pregnancies of women counseled for non-teratogenic exposure. The difference in the rate of congenital anomalies was not statistically significant [7/97 (7.2%) vs. 15/440 (3.4%), p=0.094]. The analysis was repeated among those exposed in T1 excluding genetic or cytogenetic anomalies or congenital infections [5/95 (5.3%) vs. 14/440 (3.2%), p=0.355]. There were no cases of neonatal lupus erythematosus. The gestational age at delivery was earlier, rate of preterm delivery higher, and birth weight lower, in the HCQ group. Conclusion: The present study suggests that HCQ treatment in pregnancy is not a major human teratogen. The earlier gestational age and lower birth weight might be associated with maternal disease.
AB - Objective: To evaluate pregnancy safety of hydroxychloroquine (HCQ) for rheumatologic diseases. Design: Prospective comparative observational study done at the Israeli teratology information service between 1998 and 2006. Results: 114 HCQ-exposed pregnancies (98.2% in the first trimester, T1) were followed-up and compared with 455 pregnancies of women counseled for non-teratogenic exposure. The difference in the rate of congenital anomalies was not statistically significant [7/97 (7.2%) vs. 15/440 (3.4%), p=0.094]. The analysis was repeated among those exposed in T1 excluding genetic or cytogenetic anomalies or congenital infections [5/95 (5.3%) vs. 14/440 (3.2%), p=0.355]. There were no cases of neonatal lupus erythematosus. The gestational age at delivery was earlier, rate of preterm delivery higher, and birth weight lower, in the HCQ group. Conclusion: The present study suggests that HCQ treatment in pregnancy is not a major human teratogen. The earlier gestational age and lower birth weight might be associated with maternal disease.
KW - Congenital anomalies
KW - Hydroxychloroquine
KW - Pregnancy
KW - Rheumatologic diseases
UR - http://www.scopus.com/inward/record.url?scp=84877795901&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2013.04.005
DO - 10.1016/j.reprotox.2013.04.005
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C2 - 23602891
AN - SCOPUS:84877795901
SN - 0890-6238
VL - 39
SP - 58
EP - 62
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -