Abstract
Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and emotionality. One hindlimb was then totally denervated by transecting the sciatic and saphenous nerves on one side, and autotomy, a behavior thought to be related to neuropathic pain, was quantified over 35 days. We report that OF activity and autotomy are highly variable across different strains/lines. These results reaffirm the genetic control of these behaviors. We also found that these behaviors are inversely and significantly correlated. We suggest that common genetically- determined neural mechanisms may underlie anxiety, emotionality and neuropathic pain in mice. (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 141-144 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 279 |
Issue number | 3 |
DOIs | |
State | Published - 4 Feb 2000 |
Keywords
- Autotomy
- Emotionality
- Lines
- Mice
- Motor activity
- Neuropathic pain
- Open field test
- Strains