Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice

Jean Jacques Vatine*, Marshall Devor, Inna Belfer, Pnina Raber, Rafi Zeltser, Svetlana Dolina, Ze'ev Seltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and emotionality. One hindlimb was then totally denervated by transecting the sciatic and saphenous nerves on one side, and autotomy, a behavior thought to be related to neuropathic pain, was quantified over 35 days. We report that OF activity and autotomy are highly variable across different strains/lines. These results reaffirm the genetic control of these behaviors. We also found that these behaviors are inversely and significantly correlated. We suggest that common genetically- determined neural mechanisms may underlie anxiety, emotionality and neuropathic pain in mice. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalNeuroscience Letters
Volume279
Issue number3
DOIs
StatePublished - 4 Feb 2000

Keywords

  • Autotomy
  • Emotionality
  • Lines
  • Mice
  • Motor activity
  • Neuropathic pain
  • Open field test
  • Strains

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