Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice

Jean Jacques Vatine; Marshall Devor; Inna Belfer; Pnina Raber; Rafi Zeltser; Svetlana Dolina; Ze'ev Seltzer

doi:10.1016/S0304-3940(99)00963-5

Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice

Jean Jacques Vatine^*
, Marshall Devor
, Inna Belfer
, Pnina Raber
, Rafi Zeltser
, Svetlana Dolina
, Ze'ev Seltzer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and emotionality. One hindlimb was then totally denervated by transecting the sciatic and saphenous nerves on one side, and autotomy, a behavior thought to be related to neuropathic pain, was quantified over 35 days. We report that OF activity and autotomy are highly variable across different strains/lines. These results reaffirm the genetic control of these behaviors. We also found that these behaviors are inversely and significantly correlated. We suggest that common genetically- determined neural mechanisms may underlie anxiety, emotionality and neuropathic pain in mice. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	Neuroscience Letters
Volume	279
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(99)00963-5
State	Published - 4 Feb 2000

Keywords

Autotomy
Emotionality
Lines
Mice
Motor activity
Neuropathic pain
Open field test
Strains

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10.1016/S0304-3940(99)00963-5

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title = "Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice",

abstract = "Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and emotionality. One hindlimb was then totally denervated by transecting the sciatic and saphenous nerves on one side, and autotomy, a behavior thought to be related to neuropathic pain, was quantified over 35 days. We report that OF activity and autotomy are highly variable across different strains/lines. These results reaffirm the genetic control of these behaviors. We also found that these behaviors are inversely and significantly correlated. We suggest that common genetically- determined neural mechanisms may underlie anxiety, emotionality and neuropathic pain in mice. (C) 2000 Elsevier Science Ireland Ltd.",

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AU - Vatine, Jean Jacques

AU - Devor, Marshall

AU - Belfer, Inna

AU - Raber, Pnina

AU - Zeltser, Rafi

AU - Dolina, Svetlana

AU - Seltzer, Ze'ev

PY - 2000/2/4

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KW - Autotomy

KW - Emotionality

KW - Lines

KW - Mice

KW - Motor activity

KW - Neuropathic pain

KW - Open field test

KW - Strains

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Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice

Abstract

Keywords

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