Preparation and characterization of liposomal doxorubicin for human use

Shimon Amselem*, Rivka Cohen, Shula Druckmann, Alberto Gabizon, Dorit Goren, Robert M. Abra, Anthony Huang, Roger New, Yechezkel Barenholz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A liposome-associated doxorubicin formulation that has been utilized in two phase I clinical trials at two separate medical centers is described. This work deals with formulation optimization, process development, quality control assays on raw materials, characterization assays for these liposomes, and their short-term stability. One of the main goals of this work is to provide a model for the production of liposomal formulations of sufficient quantity and quality to be used in clinical trials.

Original languageEnglish
Pages (from-to)93-123
Number of pages31
JournalJournal of Liposome Research
Volume2
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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