TY - JOUR
T1 - Preparation and characterization of liposomal doxorubicin for human use
AU - Amselem, Shimon
AU - Cohen, Rivka
AU - Druckmann, Shula
AU - Gabizon, Alberto
AU - Goren, Dorit
AU - Abra, Robert M.
AU - Huang, Anthony
AU - New, Roger
AU - Barenholz, Yechezkel
PY - 1992
Y1 - 1992
N2 - A liposome-associated doxorubicin formulation that has been utilized in two phase I clinical trials at two separate medical centers is described. This work deals with formulation optimization, process development, quality control assays on raw materials, characterization assays for these liposomes, and their short-term stability. One of the main goals of this work is to provide a model for the production of liposomal formulations of sufficient quantity and quality to be used in clinical trials.
AB - A liposome-associated doxorubicin formulation that has been utilized in two phase I clinical trials at two separate medical centers is described. This work deals with formulation optimization, process development, quality control assays on raw materials, characterization assays for these liposomes, and their short-term stability. One of the main goals of this work is to provide a model for the production of liposomal formulations of sufficient quantity and quality to be used in clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=0026736109&partnerID=8YFLogxK
U2 - 10.3109/08982109209039903
DO - 10.3109/08982109209039903
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AN - SCOPUS:0026736109
SN - 0898-2104
VL - 2
SP - 93
EP - 123
JO - Journal of Liposome Research
JF - Journal of Liposome Research
IS - 1
ER -