Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions

J. G. Hiremath; A. Rajeshkumar; D. Ickowicz; A. J. Domb

doi:10.1016/S1773-2247(13)50063-3

Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions

J. G. Hiremath^*
, A. Rajeshkumar
, D. Ickowicz
, A. J. Domb

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.

Original language	English
Pages (from-to)	439-444
Number of pages	6
Journal	Journal of Drug Delivery Science and Technology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/S1773-2247(13)50063-3
State	Published - 2013

Keywords

Drug delivery
Nanoparticles
Poly(lactic acid-co-castor oil)

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10.1016/S1773-2247(13)50063-3

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title = "Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions",

abstract = "Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40\% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.",

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doi = "10.1016/S1773-2247(13)50063-3",

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T1 - Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions

AU - Hiremath, J. G.

AU - Rajeshkumar, A.

AU - Ickowicz, D.

AU - Domb, A. J.

PY - 2013

Y1 - 2013

N2 - Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.

AB - Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.

KW - Drug delivery

KW - Nanoparticles

KW - Poly(lactic acid-co-castor oil)

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Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions

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Keywords

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