Preparation and X-ray structures of TiIV complexes of bis(carboxylato) ligands - Formation of mono-, di-, tetra-, and hexanuclear complexes with or without or and μ-O ligands

Michal Shavit, Edit Y. Tshuva

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36 Scopus citations

Abstract

Treating the amine bis(carboxylato) ligand precursor pyridine-2,6- dicarboxylic acid (H2L1) with titanium tetra(isopropoxide) gave the mononuclear octacoordinate complex L12Ti IV(dmf)2 (1), in which each carboxylato ligand binds in an η1 fashion and two solvent molecules are also coordinated to the metal. In contrast, employing the diamine bis(carboxylic acid) ligand precursor H2L2 gave a unique hexanuclear TiIV complex [TiIV6(OiPr)162-OiPr) 4(μ-L2)2] (2), where L2 = (pyridin-2-ylmethyl)amino diacetate. The crystal structure reveals that all TiIV atoms exhibit octahedral geometry, where both carboxylate and isopropoxide groups serve as bridging ligands. Surprisingly, no oxido ligands appear in the structure, which indicates that the complex, obtained at room temp., was not exposed to any traces of water. The diamine bis(carboxylato) ligand coordinates in η2 modes of both carboxyl groups to give a total of six coordination sites. Employing the same ligand with a slight change in reaction conditions, which included heating to 35°C, led to the formation of two O-bridged complexes: dinuclear [TiIV22-O)(OiPr)2-(L2)2] (3) and tetranuclear [TiIV2(μ2-O)4(L 2)4] (4), where each bis(carboxylato) ligand binds to a single Ti center in an η1 fashion, and the only bridging ligands are oxide groups, with Ti-O-Ti angles of 180.0° and 166.6° for 3 and 4, respectively, indicating π interactions in the dinuclear species. Employing a different diamine bis(carboxylato) ligand featuring a sequential connectivity of donor atoms allowed the identification of a mononuclear C2- symmetrical bis(isopropoxido) complex, L3TiIV(OiPr) 2, (5) where L3 = ethylenediamine diacetate. In 5, as opposed to 2 and similarly to 1, 4, and 5, the carboxylato ligand binds in an η1 fashion. Complexes 3, 4, and 5 are all inactive against ovarian OVCAR-1 and colon HT-29 cells.

Original languageAmerican English
Pages (from-to)1467-1474
Number of pages8
JournalEuropean Journal of Inorganic Chemistry
Issue number9
DOIs
StatePublished - Mar 2008

Keywords

  • Carboxylato ligands
  • Cluster compounds
  • Coordination modes
  • Oxido ligands
  • Titanium(iv)

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