Preparation, characterization and antileukemic properties of diaminemalonatoplatinum(II) complexes tethered to ferrocene

Ayelet Rosenfeld, Jochanan Blum*, Dan Gibson, Avner Ramu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In search for new antitumor agents with target specificity we have prepared four new complexes in which diaminemalonatoplatinum(II) moieties are covalently tethered to ferrocene - and organ specific biological carrier. The four PtAm2[(ferrocenemethyl)propanedioic acid] complexes (where Am2(NH3)2, bis(aminocyclobutane), cis- and trans-1,2-diaminocyclohexane) were characterized by 195pt NMR spectroscopy and by elemental analysis. Their activity was assessed in vitro against P388 leukemia cells. They showed considerable activity (ED50 in the 5-45 μM range) though to a smaller extent than cis-diamminedichloroplatinum(II). They are, however, more active than the previously reported complexes in which a bis(phosphinecatecholato)platinum(II) moiety was tethered to ferrocene or to ruthenocene.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalInorganica Chimica Acta
Volume201
Issue number2
DOIs
StatePublished - 15 Nov 1992

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