TY - JOUR
T1 - Preparation, characterization and antileukemic properties of diaminemalonatoplatinum(II) complexes tethered to ferrocene
AU - Rosenfeld, Ayelet
AU - Blum, Jochanan
AU - Gibson, Dan
AU - Ramu, Avner
PY - 1992/11/15
Y1 - 1992/11/15
N2 - In search for new antitumor agents with target specificity we have prepared four new complexes in which diaminemalonatoplatinum(II) moieties are covalently tethered to ferrocene - and organ specific biological carrier. The four PtAm2[(ferrocenemethyl)propanedioic acid] complexes (where Am2(NH3)2, bis(aminocyclobutane), cis- and trans-1,2-diaminocyclohexane) were characterized by 195pt NMR spectroscopy and by elemental analysis. Their activity was assessed in vitro against P388 leukemia cells. They showed considerable activity (ED50 in the 5-45 μM range) though to a smaller extent than cis-diamminedichloroplatinum(II). They are, however, more active than the previously reported complexes in which a bis(phosphinecatecholato)platinum(II) moiety was tethered to ferrocene or to ruthenocene.
AB - In search for new antitumor agents with target specificity we have prepared four new complexes in which diaminemalonatoplatinum(II) moieties are covalently tethered to ferrocene - and organ specific biological carrier. The four PtAm2[(ferrocenemethyl)propanedioic acid] complexes (where Am2(NH3)2, bis(aminocyclobutane), cis- and trans-1,2-diaminocyclohexane) were characterized by 195pt NMR spectroscopy and by elemental analysis. Their activity was assessed in vitro against P388 leukemia cells. They showed considerable activity (ED50 in the 5-45 μM range) though to a smaller extent than cis-diamminedichloroplatinum(II). They are, however, more active than the previously reported complexes in which a bis(phosphinecatecholato)platinum(II) moiety was tethered to ferrocene or to ruthenocene.
UR - http://www.scopus.com/inward/record.url?scp=4243690028&partnerID=8YFLogxK
U2 - 10.1016/S0020-1693(00)85336-0
DO - 10.1016/S0020-1693(00)85336-0
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AN - SCOPUS:4243690028
SN - 0020-1693
VL - 201
SP - 219
EP - 221
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
IS - 2
ER -