TY - JOUR
T1 - Preparation, characterization, and sterilization of hydrogel sponges for iontophoretic drug-delivery use
AU - Eljarrat-Binstock, Esther
AU - Bentolila, Alfonso
AU - Kumar, Neeraj
AU - Harel, Hannah
AU - Domb, Abraham J.
PY - 2007/9
Y1 - 2007/9
N2 - Hydrogel sponges of hydroxyethyl methacrylate (HEMA) crosslinked with ethylene glycol dimethacrylate (EGDMA) were prepared and characterized for iontophoretic drug delivery. Various parameters were examined, including: morphological structure, thermal behavior, mechanical strength, absorption capacity, swelling profile, and hydrogel stability. Three sterilization methods, gamma irradiation, ethylene oxide, and autoclave sterilizations were assessed for revealing the optimal sterilization process avoiding alteration in hydrogel properties. Hydrogels prepared with 75% water and polymerized for 24 hr seem to preserve their physical properties, swelling capacity, and absorption kinetics at least over 5 years from preparation. Gamma irradiation was found to be the most suitable as sterilization method for the dried hydrogels causing minimal alteration of hydrogel properties. This work confirmed the feasibility of preparing stable hydrogel sponges of different shapes with desired mechanical strength and swelling capacities at a rapid rate profile suitable for iontophoretic application and drug delivery.
AB - Hydrogel sponges of hydroxyethyl methacrylate (HEMA) crosslinked with ethylene glycol dimethacrylate (EGDMA) were prepared and characterized for iontophoretic drug delivery. Various parameters were examined, including: morphological structure, thermal behavior, mechanical strength, absorption capacity, swelling profile, and hydrogel stability. Three sterilization methods, gamma irradiation, ethylene oxide, and autoclave sterilizations were assessed for revealing the optimal sterilization process avoiding alteration in hydrogel properties. Hydrogels prepared with 75% water and polymerized for 24 hr seem to preserve their physical properties, swelling capacity, and absorption kinetics at least over 5 years from preparation. Gamma irradiation was found to be the most suitable as sterilization method for the dried hydrogels causing minimal alteration of hydrogel properties. This work confirmed the feasibility of preparing stable hydrogel sponges of different shapes with desired mechanical strength and swelling capacities at a rapid rate profile suitable for iontophoretic application and drug delivery.
KW - Drug delivery
KW - Hydrogel
KW - Iontophoresis
KW - Sterilization
KW - Swelling
UR - http://www.scopus.com/inward/record.url?scp=34648840125&partnerID=8YFLogxK
U2 - 10.1002/pat.948
DO - 10.1002/pat.948
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AN - SCOPUS:34648840125
SN - 1042-7147
VL - 18
SP - 720
EP - 730
JO - Polymers for Advanced Technologies
JF - Polymers for Advanced Technologies
IS - 9
ER -