Preparation of methylene-substituted calixarenes

Silvio E. Biali*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


The different synthetic approaches for the preparation of “classical” calixarenes with one, part, or all bridges chemically modified are reviewed. The methods include the cyclization of fragments, the homologous anionic ortho Fries rearrangement, the spirodienone method, the lithiation/alkylation approach, the oxidation of the bridges followed by reaction of the carbonyl units with organolithium reagents, and the bromination of the bridges followed by reaction with nucleophiles.

Original languageAmerican English
Title of host publicationCalixarenes and Beyond
Number of pages19
ISBN (Electronic)9783319318677
ISBN (Print)9783319318653
StatePublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.


  • Bromination
  • Calixarenes
  • Cyclophanes
  • Oxidation
  • Synthesis


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