Preparation of pure hydrogen peroxide and anhydrous peroxide solutions from crystalline serine perhydrate

Yitzhak Wolanov, Ovadia Lev*, Andrei V. Churakov, Alexander G. Medvedev, Vladimir M. Novotortsev, Petr V. Prikhodchenko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Hydrogen peroxide is one of the most versatile oxidation reagents, still it has not fully been exploited by synthetic chemists since anhydrous (let alone pure) hydrogen peroxide requires hazardous preparation protocols. We have recently reported on the crystallization of serine and other amino acid perhydrates, thus paving the way for a new method for laboratory-scale production of anhydrous hydrogen peroxide solutions. Serine is insoluble in most organic solvents (eg., methanol, ethyl acetate, and methyl acetate) that readily dissolve hydrogen peroxide. Moreover, since the adduct of hydrogen peroxide and serine is unstable in these organic solvents, crystalline serine perhydrate readily decomposes to give anhydrous solutions of hydrogen peroxide and crystalline precipitate of the amino acid. This procedure can then yield an anhydrous hydrogen peroxide solution in a single step. Moreover, filtration of the amino acid, and room temperature evaporation of the volatile solvent (e.g., methyl acetate), yields over 99% hydrogen peroxide.

Original languageAmerican English
Pages (from-to)5130-5133
Number of pages4
JournalTetrahedron
Volume66
Issue number27-28
DOIs
StatePublished - 3 Jul 2010

Keywords

  • Amino acid perhydrate
  • Anhydrous hydrogen peroxide
  • Hydrogen peroxide
  • Pure hydrogen peroxide

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