TY - JOUR
T1 - Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes
AU - Engelberg, Nathan
AU - Bino, Avi
AU - Tshuva, Edit Y.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti4O6(Hcit)3(cit)]9− 1, as it appears in the compound [Co(NH3)6]3[Ti4O6(Hcit)3(cit)]⋅20H2O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti4O6} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH2COOH group. An additional already known Ti(IV) complex [Ti(Hcit3−)3]5− 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.
AB - Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti4O6(Hcit)3(cit)]9− 1, as it appears in the compound [Co(NH3)6]3[Ti4O6(Hcit)3(cit)]⋅20H2O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti4O6} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH2COOH group. An additional already known Ti(IV) complex [Ti(Hcit3−)3]5− 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.
UR - http://www.scopus.com/inward/record.url?scp=85078114714&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2020.119429
DO - 10.1016/j.ica.2020.119429
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AN - SCOPUS:85078114714
SN - 0020-1693
VL - 503
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
M1 - 119429
ER -
