TY - JOUR
T1 - Presence of infective Epstein‐Barr virus in the urine of patients with infectious mononucleosis
AU - Landau, Zvi
AU - Gross, Raz
AU - Sanilevich, Anka
AU - Friedmann, Adam
AU - Mitrani‐Rosenbaum, Stella
PY - 1994/11
Y1 - 1994/11
N2 - The presence of Epstein‐Barr virus (EBV) in the blood and urine of 20 patients with infectious mononucleosis (IM) was investigated together with the clinical course of the disease, and in 9 patients up to 2–7 months after recovery. EBV DNA, analyzed by the polymerase chain reaction (PCR), was detected in the blood of all 20 patients from the first sample obtained and detected between 3 to 42 days from the beginning of symptoms and up to 2–3 months after recovery. In the urine, EBV DNA was detected in 15 out of 16 (93%) patients in the first sample obtained and detected between 3 to 50 days during the clinical course of the disease. In four patients EBV DNA was detected in the urine up to 3 months after full recovery. Seventeen out of 26 (65%) urine samples including 3 which were obtained 2–7 months after recovery infected B cells as assessed by PCR. Nine out of 12 (75%) urine samples tested induced Epstein‐Barr nuclear antigen (EBNA) in the infected B‐cell line. In addition to the persistence of EBV in the blood of IM patients, these studies show for the first time the presence of infective EBV in the urine during the clinical course of the disease and up to 7 months after full clinical recovery. © 1994 Wiley‐Liss, Inc.
AB - The presence of Epstein‐Barr virus (EBV) in the blood and urine of 20 patients with infectious mononucleosis (IM) was investigated together with the clinical course of the disease, and in 9 patients up to 2–7 months after recovery. EBV DNA, analyzed by the polymerase chain reaction (PCR), was detected in the blood of all 20 patients from the first sample obtained and detected between 3 to 42 days from the beginning of symptoms and up to 2–3 months after recovery. In the urine, EBV DNA was detected in 15 out of 16 (93%) patients in the first sample obtained and detected between 3 to 50 days during the clinical course of the disease. In four patients EBV DNA was detected in the urine up to 3 months after full recovery. Seventeen out of 26 (65%) urine samples including 3 which were obtained 2–7 months after recovery infected B cells as assessed by PCR. Nine out of 12 (75%) urine samples tested induced Epstein‐Barr nuclear antigen (EBNA) in the infected B‐cell line. In addition to the persistence of EBV in the blood of IM patients, these studies show for the first time the presence of infective EBV in the urine during the clinical course of the disease and up to 7 months after full clinical recovery. © 1994 Wiley‐Liss, Inc.
KW - B‐cell line
KW - EBNA
KW - PCR
UR - http://www.scopus.com/inward/record.url?scp=0028131710&partnerID=8YFLogxK
U2 - 10.1002/jmv.1890440303
DO - 10.1002/jmv.1890440303
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C2 - 7852965
AN - SCOPUS:0028131710
SN - 0146-6615
VL - 44
SP - 229
EP - 233
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 3
ER -