Prestimulus Activity in the Cingulo-Opercular Network Predicts Memory for Naturalistic Episodic Experience

Noga Cohen*, Aya Ben-Yakov, Jochen Weber, Micah G. Edelson, Rony Paz, Yadin Dudai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Human memory is strongly influenced by brain states occurring before an event, yet we know little about the underlying mechanisms. We found that activity in the cingulo-opercular network (including bilateral anterior insula [aI] and anterior prefrontal cortex [aPFC]) seconds before an event begins can predict whether this event will subsequently be remembered. We then tested how activity in the cingulo-opercular network shapes memory performance. Our findings indicate that prestimulus cingulo-opercular activity affects memory performance by opposingly modulating subsequent activity in two sets of regions previously linked to encoding and retrieval of episodic information. Specifically, higher prestimulus cingulo-opercular activity was associated with a subsequent increase in activity in temporal regions previously linked to encoding and with a subsequent reduction in activity within a set of regions thought to play a role in retrieval and self-referential processing. Together, these findings suggest that prestimulus attentional states modulate memory for real-life events by enhancing encoding and possibly by dampening interference from competing memory substrates.

Original languageAmerican English
Pages (from-to)1902-1913
Number of pages12
JournalCerebral Cortex
Volume30
Issue number3
DOIs
StatePublished - 14 Mar 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

Keywords

  • cingulo-opercular network
  • episodic memory
  • fMRI
  • prestimulus
  • subsequent memory

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