Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.
|Original language||American English|
|Number of pages||3|
|Journal||European Annals of Otorhinolaryngology, Head and Neck Diseases|
|State||Published - Apr 2019|
Bibliographical noteFunding Information:
This study was supported by a grant from General Recycling Industries Ltd, Edmonton, Alberta, Canada.
© 2018 Elsevier Masson SAS
- Sudden sensorineural hearing loss