Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

H. Tovi; H. Ovadia; R. Eliashar; M. A. de Jong; M. Gross

doi:10.1016/j.anorl.2017.11.013

Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

H. Tovi, H. Ovadia, R. Eliashar, M. A. de Jong, M. Gross^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.

Original language	English
Pages (from-to)	99-101
Number of pages	3
Journal	European Annals of Otorhinolaryngology, Head and Neck Diseases
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.anorl.2017.11.013
State	Published - Apr 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Masson SAS

Keywords

Anti-prestin
Autoantibodies
Elisa
Prestin
Sudden sensorineural hearing loss

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title = "Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss",

abstract = "Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.",

keywords = "Anti-prestin, Autoantibodies, Elisa, Prestin, Sudden sensorineural hearing loss",

author = "H. Tovi and H. Ovadia and R. Eliashar and {de Jong}, {M. A.} and M. Gross",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Masson SAS",

year = "2019",

month = apr,

doi = "10.1016/j.anorl.2017.11.013",

language = "אנגלית",

volume = "136",

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journal = "European Annals of Otorhinolaryngology, Head and Neck Diseases",

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T1 - Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

AU - Tovi, H.

AU - Ovadia, H.

AU - Eliashar, R.

AU - de Jong, M. A.

AU - Gross, M.

PY - 2019/4

Y1 - 2019/4

N2 - Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.

AB - Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.

KW - Anti-prestin

KW - Autoantibodies

KW - Elisa

KW - Prestin

KW - Sudden sensorineural hearing loss

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VL - 136

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JO - European Annals of Otorhinolaryngology, Head and Neck Diseases

JF - European Annals of Otorhinolaryngology, Head and Neck Diseases

IS - 2

ER -

Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

Abstract

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Keywords

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