Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss

H. Tovi, H. Ovadia, R. Eliashar, M. A. de Jong, M. Gross*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objectives: To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Design: Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed. Results: Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: −1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters. Conclusions: This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.

Original languageAmerican English
Pages (from-to)99-101
Number of pages3
JournalEuropean Annals of Otorhinolaryngology, Head and Neck Diseases
Volume136
Issue number2
DOIs
StatePublished - Apr 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Masson SAS

Keywords

  • Anti-prestin
  • Autoantibodies
  • Elisa
  • Prestin
  • Sudden sensorineural hearing loss

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