Prevention of experimental allergic encephalomyelitis by anterior hypothalamic lesion in rats

Elyiahu Wertman; Haim Ovadia; Shaul Feldman; Oded Abramsky

doi:10.1212/wnl.35.10.1468

Prevention of experimental allergic encephalomyelitis by anterior hypothalamic lesion in rats

Elyiahu Wertman^*
, Haim Ovadia
, Shaul Feldman
, Oded Abramsky

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Bilateral electrical lesions were performed in the anterior hypothalamus (AH) and hippocampus (HC) of female Lewis rats. AH but not HC lesions were found to inhibit the appearance of clinical signs typical of experimental allergic encephalomyelitis (EAE). The incidence of EAE was 17.2% and the duration was 1.33 ± 0.07 days after AH lesions compared with an incidence of 85% and duration of 4.81 ± 0.6 days in the controls. Destruction of the AH was followed by decreased levels of antibodies to myelin basic protein and increased reactivity of splenic lymphocytes to concanavalin A, but did not affect the extent of mono-nuclear cell infiltration within the brain and spinal cord.

Original language	English
Pages (from-to)	1468-1470
Number of pages	3
Journal	Neurology
Volume	35
Issue number	10
DOIs	https://doi.org/10.1212/wnl.35.10.1468
State	Published - Oct 1985

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title = "Prevention of experimental allergic encephalomyelitis by anterior hypothalamic lesion in rats",

abstract = "Bilateral electrical lesions were performed in the anterior hypothalamus (AH) and hippocampus (HC) of female Lewis rats. AH but not HC lesions were found to inhibit the appearance of clinical signs typical of experimental allergic encephalomyelitis (EAE). The incidence of EAE was 17.2\% and the duration was 1.33 ± 0.07 days after AH lesions compared with an incidence of 85\% and duration of 4.81 ± 0.6 days in the controls. Destruction of the AH was followed by decreased levels of antibodies to myelin basic protein and increased reactivity of splenic lymphocytes to concanavalin A, but did not affect the extent of mono-nuclear cell infiltration within the brain and spinal cord.",

author = "Elyiahu Wertman and Haim Ovadia and Shaul Feldman and Oded Abramsky",

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AU - Wertman, Elyiahu

AU - Ovadia, Haim

AU - Feldman, Shaul

AU - Abramsky, Oded

PY - 1985/10

Y1 - 1985/10

N2 - Bilateral electrical lesions were performed in the anterior hypothalamus (AH) and hippocampus (HC) of female Lewis rats. AH but not HC lesions were found to inhibit the appearance of clinical signs typical of experimental allergic encephalomyelitis (EAE). The incidence of EAE was 17.2% and the duration was 1.33 ± 0.07 days after AH lesions compared with an incidence of 85% and duration of 4.81 ± 0.6 days in the controls. Destruction of the AH was followed by decreased levels of antibodies to myelin basic protein and increased reactivity of splenic lymphocytes to concanavalin A, but did not affect the extent of mono-nuclear cell infiltration within the brain and spinal cord.

AB - Bilateral electrical lesions were performed in the anterior hypothalamus (AH) and hippocampus (HC) of female Lewis rats. AH but not HC lesions were found to inhibit the appearance of clinical signs typical of experimental allergic encephalomyelitis (EAE). The incidence of EAE was 17.2% and the duration was 1.33 ± 0.07 days after AH lesions compared with an incidence of 85% and duration of 4.81 ± 0.6 days in the controls. Destruction of the AH was followed by decreased levels of antibodies to myelin basic protein and increased reactivity of splenic lymphocytes to concanavalin A, but did not affect the extent of mono-nuclear cell infiltration within the brain and spinal cord.

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Prevention of experimental allergic encephalomyelitis by anterior hypothalamic lesion in rats

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