Primary Auditory Cortex is Required for Anticipatory Motor Response

Jingcheng Li, Xiang Liao, Jianxiong Zhang, Meng Wang, Nian Yang, Jun Zhang, Guanghui Lv, Haohong Li, Jian Lu, Ran Ding, Xingyi Li, Yu Guang, Zhiqi Yang, Han Qin, Wenjun Jin, Kuan Zhang, Chao He, Hongbo Jia, Shaoqun Zeng, Zhian HuIsrael Nelken, Xiaowei Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The ability of the brain to predict future events based on the pattern of recent sensory experience is critical for guiding animal's behavior. Neocortical circuits for ongoing processing of sensory stimuli are extensively studied, but their contributions to the anticipation of upcoming sensory stimuli remain less understood. We, therefore, used in vivo cellular imaging and fiber photometry to record mouse primary auditory cortex to elucidate its role in processing anticipated stimulation. We found neuronal ensembles in layers 2/3, 4, and 5 which were activated in relationship to anticipated sound events following rhythmic stimulation. These neuronal activities correlated with the occurrence of anticipatory motor responses in an auditory learning task. Optogenetic manipulation experiments revealed an essential role of such neuronal activities in producing the anticipatory behavior. These results strongly suggest that the neural circuits of primary sensory cortex are critical for coding predictive information and transforming it into anticipatory motor behavior.

Original languageAmerican English
Pages (from-to)3254-3271
Number of pages18
JournalCerebral Cortex
Volume27
Issue number6
DOIs
StatePublished - 1 Jun 2017

Bibliographical note

Publisher Copyright:
© The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Keywords

  • 2-photon imaging
  • anticipatory motor response
  • predictive coding
  • primary auditory cortex
  • rhythmic sound stimulation

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