Primary B cells essentially lack constitutive NF-κB activity

Yifat Yedidia, Yinon Ben-Neriah, Steffen Jung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Based primarily on the analysis of B cell lines, mature B cells are considered distinct from non-B cells and immature B cells by having constitutive nuclear NF-κB activity. By their comparison to splenic non-B cells or activated B cells we show here that primary resting B cells lack cell-autonomous NF-κB activity. This finding indicates that the role of the transcription factor in B cells is similar to that in other cells, namely a common mediator of activation and stress signals. Whereas the absence of constitutive NF-κB activity in mature B cells does not argue against a role of NF-κB in B cell development, it does not support the notion of the essential function of the factor in maintaining the unique transcriptional activities in B cells.

Original languageAmerican English
Pages (from-to)30-36
Number of pages7
JournalEuropean Journal of Immunology
Issue number1
StatePublished - Jan 1998


  • NF-κB activity
  • Primary B cells


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