Abstract
Based primarily on the analysis of B cell lines, mature B cells are considered distinct from non-B cells and immature B cells by having constitutive nuclear NF-κB activity. By their comparison to splenic non-B cells or activated B cells we show here that primary resting B cells lack cell-autonomous NF-κB activity. This finding indicates that the role of the transcription factor in B cells is similar to that in other cells, namely a common mediator of activation and stress signals. Whereas the absence of constitutive NF-κB activity in mature B cells does not argue against a role of NF-κB in B cell development, it does not support the notion of the essential function of the factor in maintaining the unique transcriptional activities in B cells.
Original language | English |
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Pages (from-to) | 30-36 |
Number of pages | 7 |
Journal | European Journal of Immunology |
Volume | 28 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1998 |
Keywords
- NF-κB activity
- Primary B cells