TY - JOUR
T1 - Principles for coding associative memories in a compact neural network
AU - Pritz, Christian
AU - Itskovits, Eyal
AU - Bokman, Eduard
AU - Ruach, Rotem
AU - Gritsenko, Vladimir
AU - Nelken, Tal
AU - Menasherof, Mai
AU - Azulay, Aharon
AU - Zaslaver, Alon
N1 - Publisher Copyright:
© Pritz et al.
PY - 2023
Y1 - 2023
N2 - A major goal in neuroscience is to elucidate the principles by which memories are stored in a neural network. Here, we have systematically studied how four types of associative memories (short-and long-term memories, each as positive and negative associations) are encoded within the compact neural network of Caenorhabditis elegans worms. Interestingly, sensory neurons were primarily involved in coding short-term, but not long-term, memories, and individual sensory neurons could be assigned to coding either the conditioned stimulus or the experience valence (or both). Moreover, when considering the collective activity of the sensory neurons, the specific training experiences could be decoded. Interneurons integrated the modulated sensory inputs and a simple linear combination model identified the experience-specific modulated communication routes. The widely distributed memory suggests that integrated network plasticity, rather than changes to individual neurons, underlies the fine behavioral plasticity. This comprehensive study reveals basic memory-coding principles and highlights the central roles of sensory neurons in memory formation.
AB - A major goal in neuroscience is to elucidate the principles by which memories are stored in a neural network. Here, we have systematically studied how four types of associative memories (short-and long-term memories, each as positive and negative associations) are encoded within the compact neural network of Caenorhabditis elegans worms. Interestingly, sensory neurons were primarily involved in coding short-term, but not long-term, memories, and individual sensory neurons could be assigned to coding either the conditioned stimulus or the experience valence (or both). Moreover, when considering the collective activity of the sensory neurons, the specific training experiences could be decoded. Interneurons integrated the modulated sensory inputs and a simple linear combination model identified the experience-specific modulated communication routes. The widely distributed memory suggests that integrated network plasticity, rather than changes to individual neurons, underlies the fine behavioral plasticity. This comprehensive study reveals basic memory-coding principles and highlights the central roles of sensory neurons in memory formation.
UR - http://www.scopus.com/inward/record.url?scp=85159551626&partnerID=8YFLogxK
U2 - 10.7554/eLife.74434
DO - 10.7554/eLife.74434
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C2 - 37140557
AN - SCOPUS:85159551626
SN - 2050-084X
VL - 12
JO - eLife
JF - eLife
M1 - e74434
ER -