Principles for coding associative memories in a compact neural network

Christian Pritz, Eyal Itskovits, Eduard Bokman, Rotem Ruach, Vladimir Gritsenko, Tal Nelken, Mai Menasherof, Aharon Azulay, Alon Zaslaver*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A major goal in neuroscience is to elucidate the principles by which memories are stored in a neural network. Here, we have systematically studied how four types of associative memories (short-and long-term memories, each as positive and negative associations) are encoded within the compact neural network of Caenorhabditis elegans worms. Interestingly, sensory neurons were primarily involved in coding short-term, but not long-term, memories, and individual sensory neurons could be assigned to coding either the conditioned stimulus or the experience valence (or both). Moreover, when considering the collective activity of the sensory neurons, the specific training experiences could be decoded. Interneurons integrated the modulated sensory inputs and a simple linear combination model identified the experience-specific modulated communication routes. The widely distributed memory suggests that integrated network plasticity, rather than changes to individual neurons, underlies the fine behavioral plasticity. This comprehensive study reveals basic memory-coding principles and highlights the central roles of sensory neurons in memory formation.

Original languageAmerican English
Article numbere74434
JournaleLife
Volume12
DOIs
StatePublished - 2023

Bibliographical note

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© Pritz et al.

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