TY - JOUR
T1 - Proactive forensic science
T2 - A novel class of cathinone precursors
AU - Smolianitski, E.
AU - Wolf, E.
AU - Almog, J.
PY - 2014/9
Y1 - 2014/9
N2 - Nine new derivatives of cathinone, which are not covered by present illicit-drug laws in Israel and other countries have been synthesized and characterized. Unlike most of the modified cathinones on the illicit drug market, these compounds are obtained by modifying the carbonyl group of the parent compound. The new group contains cyclic ketals and thioketals, oximes and hydrazone, of cathinone and of cathinone phthalimide. Cathinone is readily regenerated from the new derivatives by acid hydrolysis. Consequently, they can be regarded as potential pro-drugs, and their inclusion in the illicit-drugs bylaws should be considered.
AB - Nine new derivatives of cathinone, which are not covered by present illicit-drug laws in Israel and other countries have been synthesized and characterized. Unlike most of the modified cathinones on the illicit drug market, these compounds are obtained by modifying the carbonyl group of the parent compound. The new group contains cyclic ketals and thioketals, oximes and hydrazone, of cathinone and of cathinone phthalimide. Cathinone is readily regenerated from the new derivatives by acid hydrolysis. Consequently, they can be regarded as potential pro-drugs, and their inclusion in the illicit-drugs bylaws should be considered.
KW - Cathinone
KW - Designer drugs
KW - Ketals
KW - Proactive forensic science
KW - Thioketals
UR - http://www.scopus.com/inward/record.url?scp=84905234674&partnerID=8YFLogxK
U2 - 10.1016/j.forsciint.2014.06.020
DO - 10.1016/j.forsciint.2014.06.020
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AN - SCOPUS:84905234674
SN - 0379-0738
VL - 242
SP - 219
EP - 227
JO - Forensic Science International
JF - Forensic Science International
ER -