Probing biocatalytic transformations with CdSe-ZnS QDs

Ron Gill, Ronit Freeman, Jian Ping Xu, Itamar Willner*, Shira Winograd, Itzik Shweky, Uri Banin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


CdSe/ZnS QDs enable the optical probing of the biocatalytic oxidation of tyrosine derivatives and of the scission of peptides by thrombin. CdSe/ZnS QDs were modified with tyrosine methyl ester or with a tyrosine-containing peptide. The tyrosine units were reacted with tyrosinase/O2 to yield the respective l-DOPA and quinone derivatives. The luminescence of QDs modified by the enzyme-generated quinone units is quenched. The quinone-functionalized peptide associated with the QDs was cleaved by thrombin, a process that restored the luminescence of the QDs.

Original languageAmerican English
Pages (from-to)15376-15377
Number of pages2
JournalJournal of the American Chemical Society
Issue number48
StatePublished - 6 Dec 2006


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