Procalcitonin in hemodialysis patients presenting with fever or chills to the emergency department

R. Schneider, M. J. Cohen, S. Benenson*, O. Duchin, Y. S. Haviv, M. Elhalel-Darnitski, P. D. Levin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We sought to assess the role of procalcitonin in discriminating severe bacterial infections requiring antibiotic treatment from non-bacterial causes of fever or chills in chronic dialysis patients. Chronic hemodialysis patients who were admitted to the emergency room due to fever and/or chills were recruited to the study. The presence or absence of bacterial infection was defined after recruitment conclusion by an infectious disease specialist who was blinded to procalcitonin results. Procalcitonin levels were compared between infected and non-infected patients. Out of 54 patients recruited, 22 (41%) patients eventually diagnosed with infection. Mean (± SD) procalcitonin values were 4.3 (± 5.5) ng/ml among cases, 1.0 (± 2.0) ng/ml among controls with no infection (p = 0.02). A cutoff PCT value of 1 ng/ml or higher had 77% sensitivity and 59% specificity for the diagnosis of severe infection. Procalcitonin cannot usefully identify hemodialysis patient with bacterial infection.

Original languageAmerican English
Pages (from-to)257-262
Number of pages6
JournalInternal and Emergency Medicine
Volume15
Issue number2
DOIs
StatePublished - 1 Mar 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, Società Italiana di Medicina Interna (SIMI).

Keywords

  • Bacterial infection
  • Hemodialysis
  • Procalcitonin

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