Production and characterization of interferon from endothelial cells

Stefan Einhorn*, Israel Vlodavsky, Zvi Fuks, Amiram Eldor, Amos Panet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The capacity of cultured bovine aortic, capillary, and corneal endothelial cells as well as of human umbilical cord endothelial cells to produce interferon (IFN) was investigated. The endothelial cells of the two species produced significant amounts of IFN in response to various viruses and poly (I) poly (C). The IFN produced by human umbilical cord endothelial cells was a mixture of α‐ and β‐IFN, as determined by neutralization with antibodies directed against these two types of IFNs as well as by measuring the antiviral activity on heterologous cells. Bovine endothelial cells also produced a mixture of at least two IFN subspecies, one of them labile at pH 2 and active on human cells and the other stable at pH 2 and inactive on human cells.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalJournal of Cellular Physiology
Volume122
Issue number2
DOIs
StatePublished - Feb 1985

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