TY - JOUR
T1 - Production and characterization of interferon from endothelial cells
AU - Einhorn, Stefan
AU - Vlodavsky, Israel
AU - Fuks, Zvi
AU - Eldor, Amiram
AU - Panet, Amos
PY - 1985/2
Y1 - 1985/2
N2 - The capacity of cultured bovine aortic, capillary, and corneal endothelial cells as well as of human umbilical cord endothelial cells to produce interferon (IFN) was investigated. The endothelial cells of the two species produced significant amounts of IFN in response to various viruses and poly (I) poly (C). The IFN produced by human umbilical cord endothelial cells was a mixture of α‐ and β‐IFN, as determined by neutralization with antibodies directed against these two types of IFNs as well as by measuring the antiviral activity on heterologous cells. Bovine endothelial cells also produced a mixture of at least two IFN subspecies, one of them labile at pH 2 and active on human cells and the other stable at pH 2 and inactive on human cells.
AB - The capacity of cultured bovine aortic, capillary, and corneal endothelial cells as well as of human umbilical cord endothelial cells to produce interferon (IFN) was investigated. The endothelial cells of the two species produced significant amounts of IFN in response to various viruses and poly (I) poly (C). The IFN produced by human umbilical cord endothelial cells was a mixture of α‐ and β‐IFN, as determined by neutralization with antibodies directed against these two types of IFNs as well as by measuring the antiviral activity on heterologous cells. Bovine endothelial cells also produced a mixture of at least two IFN subspecies, one of them labile at pH 2 and active on human cells and the other stable at pH 2 and inactive on human cells.
UR - http://www.scopus.com/inward/record.url?scp=0021918928&partnerID=8YFLogxK
U2 - 10.1002/jcp.1041220206
DO - 10.1002/jcp.1041220206
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C2 - 2578473
AN - SCOPUS:0021918928
SN - 0021-9541
VL - 122
SP - 200
EP - 204
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 2
ER -