Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils

Robert A. Seder, William E. Paul, S. Zami Ben-Sasson, Graham S. Legros, Marshall Plaut*, S. Zami Ben-Sasson, Anne Kagey-Sobotka, Marshall Plaut*, Fred D. Finkelman, Jacalyn H. Pierce

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Interleukin-3 (IL-3)-dependent mast cell lines, upon stimulation by calcium ionophores or by FcεRI cross-linking, express mRNA for, and secrete, a distinct pattern of cytokines, similar to those secreted by cloned mouse T cells of the TH2 type. The mast-cell-derived cytokines include IL-3, IL-4, IL-5 and IL-6. Not only in vitro mast cell lines, but also in vivo derived peritoneal mast cells secrete cytokines. An in vivo derived cell, in mouse spleen and bone marrow, secretes IL-4 and other cytokines upon stimulation with calcium ionophores or by FcεRI cross-linking or FcRII cross-linking. The IL-4-producing cells are highly enriched in the FcεR+ subset of spleen and bone marrow cells. These FcεR+ cells produce large amounts of IL-4, and they have characteristics similar to those of immature mast cells and/or basophils. It is possible that cytokines produced by mast cells and/or basophils participate in allergic inflammatory diseases.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume94
Issue number1-4
DOIs
StatePublished - 1991
Externally publishedYes

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