Profibrotic and Angiogenic Factors in Asthma

Neville Berkman*, Francesca Levi-Schaffer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations
Original languageAmerican English
Title of host publicationInflammation and Allergy Drug Design
Number of pages16
ISBN (Print)9781444330144
StatePublished - 27 Jul 2011


  • Airway hyperresponsiveness (AHR) - component of asthma, optimal anti-inflammatory therapy
  • Airway remodeling, prominent pathophysiologic - feature of chronic asthma
  • Asthma and airway fibrosis - increase in fibroblasts, differentiation of myofibroblasts in asthma
  • Attenuation of angiogenesis - and cancer therapies, VEGF pathway as key regulator of angiogenesis
  • Eosinophils and angiogenesis - eosinophil contribution to angiogenesis, in asthma
  • Interleukin 4 and interleukin 13 - cytokines from Th2 cells, mediators in asthma
  • Nerve growth factor (NGF), important neurotrophic agent - produced in airways
  • Profibrotic and - angiogenic factors in asthma
  • Transforming growth factor beta - TGF-β superfamily, over 30 different proteins and BMPs
  • Transforming growth factor beta - critical for embryogenesis and tissue repair, role in mediating immune responses

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