Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling

Julia Zeitlinger*, Itamar Simon, Christopher T. Harbison, Nancy M. Hannett, Thomas L. Volkert, Gerald R. Fink, Richard A. Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

186 Scopus citations


Specialized gene expression programs are induced by signaling pathways that act on transcription factors. Whether these transcription factors can function in multiple developmental programs through a global switch in promoter selection is not known. We have used genome-wide location analysis to show that the yeast Ste12 transcription factor, which regulates mating and filamentous growth, is bound to distinct program-specific target genes dependent on the developmental condition. This condition-dependent distribution of Ste12 requires concurrent binding of the transcription factor Tec1 during filamentation and is differentially regulated by the MAP kinases Fus3 and Kss1. Program-specific distribution across the genome may be a general mechanism by which transcription factors regulate distinct gene expression programs in response to signaling.

Original languageAmerican English
Pages (from-to)395-404
Number of pages10
Issue number3
StatePublished - 2 May 2003

Bibliographical note

Funding Information:
We are grateful to Hiten Madhani for many helpful suggestions; Lutz Kockel, Joan Richmond, and Ann Schlesinger for critical reading of the manuscript; Geoffrey Montgomery, Chris Nelson, Ben Gordon, Manolis Kamvysselis, Richard Jenner, and members of the Young and Fink lab for help and discussions; and Tim Köhler for sending reagents. This work was supported by the Human Frontier Science Program (J.Z.).


Dive into the research topics of 'Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling'. Together they form a unique fingerprint.

Cite this