Progress in modeling of protein structures and interactions

Ora Schueler-Furman, Chu Wang, Phil Bradley, Kira Misura, David Baker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

250 Scopus citations


The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

Original languageAmerican English
Pages (from-to)638-642
Number of pages5
Issue number5748
StatePublished - 28 Oct 2005


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