Promotion of leishmanial infections in non-permissive host macrophages by conditioned medium

Emanuela Handman*, Charles L. Greenblatt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Leishmania enriettii grows well in guinea pig macrophages in culture but fails to do so in mouse macrophages. Dialyzed and concentrated conditioned medium from L. enriettii cultures promoted the infection in the mouse macrophages at 37° C and at 32° C. Similarly processed medium on which L. tropica had been cultured did not cause the same effect. Immune precipitation of the conditioned medium by anti-Leishmania serum cancelled out the effect. Infections of guinea pig macrophages by L. tropica were also enhanced by the homologous medium, but we were unable to quantitate the effect.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalParasitology Research
Volume53
Issue number2
DOIs
StatePublished - Jan 1977

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