Propionibacterium endocarditis: A case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study

Tahaniyat Lalani*, Anna K. Person, Susan S. Hedayati, Laura Moore, David R. Murdoch, Bruno Hoen, Gail Peterson, Hasan Shahbaz, Didier Raoult, Jose M. Miro, Lars Olaison, Ulrika Snygg-Martin, Fredy Suter, Dennis Spelman, Susannah Eykyn, Jacob Strahilevitz, Jan T. Van Der Meer, Dominique Verhagen, Khaula Baloch, Elias AbrutynChristopher H. Cabell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Propionibacterium species are occasionally associated with serious systemic infections such as infective endocarditis. In this study, we examined the clinical features, complications and outcome of 15 patients with Propionibacterium endocarditis using the International Collaboration on Endocarditis Merged Database (ICE-MD) and Prospective Cohort Study (ICE-PCS), and compared the results to 28 cases previously reported in the literature. In the ICE database, 11 of 15 patients were male with a mean age of 52 y. Prosthetic valve endocarditis occurred in 13 of 15 cases and 3 patients had a history of congenital heart disease. Clinical findings included valvular vegetations (9 patients), cardiac abscesses (3 patients), congestive heart failure (2 patients), and central nervous system emboli (2 patients). Most patients were treated with β-lactam antibiotics alone or in combination for 4 to 6 weeks. 10 of the 15 patients underwent valve replacement surgery and 2 patients died. Similar findings were noted on review of the literature. The results of this paper suggest that risk factors for Propionibacterium endocarditis include male gender, presence of prosthetic valves and congenital heart disease. The clinical course is characterized by complications such as valvular dehiscence, cardiac abscesses and congestive heart failure. Treatment may require a combination of medical and surgical therapy.

Original languageAmerican English
Pages (from-to)840-848
Number of pages9
JournalScandinavian Journal of Infectious Diseases
Volume39
Issue number10
DOIs
StatePublished - 2007
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by the National Institutes of Health (grant HL70861 (to C.H.C.)), the Tenet Healthcare Foundation (E.A.), the ‘Red Española de Investigación en Patología Infecciosa (V-2003-REDC14A-O)’ (J.M.M.); and the Funda-ción Privada Máximo Soriano Jiménez (J.M.M.).

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