Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells

Srivatsan Kidambi*, Joel Yarmush, Wayne Fong, Sangeetha Kamath, Joseph Schianodicola, Yaakov Nahmias

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This study explored the effects of propofol on c-Fos and Egr-1 in neuroblastoma (N2A) cells. We demonstrate that propofol induced the expression of c-Fos and Egr-1 within 30 and 60min of exposure time. At 16.8μM concentration, propofol induced a 6 and 2.5-fold expression of c-Fos and Egr-1, respectively. However, at concentrations above 100μM, propofol failed to induce expression of c-Fos or Egr-1. Propofol-induced c-Fos and Egr-1 transcription was unaffected by bicuculline, a γ-aminobutyric acid-A receptor antagonist, but was abolished by PD98059, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor. Our study shows that clinically relevant concentrations of propofol induce c-Fos and Egr-1 expression through an extracellular signal-regulated kinase mediated and γ-aminobutyric acid-A independent pathway.

Original languageAmerican English
Pages (from-to)657-662
Number of pages6
Issue number7
StatePublished - 6 May 2009
Externally publishedYes


  • Extracellular signal-regulated kinase
  • Immediate early genes
  • Propofol
  • γ-aminobutyric acid


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